Search results for "Responsive hydrogel"
showing 2 items of 2 documents
Pulsatile protein release and protection using radiation-crosslinked polypeptide hydrogel delivery devices
2011
Abstract In the recent years recombinant technology has identified numerous protein based therapeutics. Their effective delivery, though, can be challenging due to the poor stability of most proteins along their pathway to the target site in the body. Hydrogels have been identified as good candidates for protein encapsulation and delivery thanks to both material and manufacturing process advantages. In this work we propose high energy irradiation as a synthetic methodology of choice to engineer hydrogel-based delivery devices for encapsulation and pulsatile release of proteins, triggered by pH, and for prevention of their denaturation when encapsulated. In particular, maleic anhydride funct…
Synthesis, characterisation and properties of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide-graft-maleic anhydride precursors and their stimuli-responsiv…
2009
Abstract A family of poly(amino acid)-maleic anhydride hydrogels were designed and synthesized. Water soluble polymeric precursors were prepared by partially substituting the hydroxyl groups of the α,β-poly( N -2-hydroxyethyl)- dl -aspartamide backbone with maleic anhydride, so as to provide double bonds for crosslinking and carboxylic acid groups for pH and electric field responsiveness. Reaction conditions (reactive mixture composition and catalysis) were systematically varied in order to obtain PHEA–MA precursors with different and reliable graft-maleic anhydride levels. PHEA–MA precursors were characterised by titration, Nuclear Magnetic Resonance ( 1 H NMR), Fourier-Transformed Infrare…